N-Heterocyclic Carbene-Catalyzed Mukaiyama Aldol Reactions
- 13 February 2007
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 9 (6), 1013-1016
- https://doi.org/10.1021/ol0630494
Abstract
N-Heterocyclic carbenes were shown to be highly effective catalysts to promote Mukaiyama aldol reactions. In the presence of only 0.5 mol % of N-heterocyclic carbene (5), various aldehydes and 2,2,2-trifluoroacetophenone underwent Mukaiyama aldol reactions in THF with trimethylsilyl ketene acetal (2) at 23 °C as well as with trimethylsilyl enol ether (7) at 0 °C to afford aldol adducts in good yields. These conditions are extremely mild and operationally simple and tolerate various functional groups.Keywords
This publication has 77 references indexed in Scilit:
- Asymmetric Synthesis of Chromanones via N-Heterocyclic Carbene Catalyzed Intramolecular Crossed-Benzoin ReactionsSynlett, 2006
- Thiazolium-Catalyzed Additions of Acylsilanes: A General Strategy for Acyl Anion Addition ReactionsThe Journal of Organic Chemistry, 2006
- Zn(pybox)-Complex-Catalyzed Asymmetric Aqueous Mukaiyama-Aldol ReactionsThe Journal of Organic Chemistry, 2006
- Synthesis of phosphorus esters by transesterification mediated by N-heterocyclic carbenes (NHCs)Chemical Communications, 2005
- Explorations into New Reaction ChemistryAngewandte Chemie International Edition, 2004
- First example of chiral N-heterocyclic carbenes as catalysts for kinetic resolutionChemical Communications, 2004
- Lithium Acetate-Catalyzed Aldol Reaction between Aldehyde and Trimethylsilyl Enolate in Anhydrous or Water-Containing N,N-DimethylformamideBulletin of the Chemical Society of Japan, 2004
- Product‐Catalyzed Aldol Reaction between Trimethylsilyl Enolates and AldehydesAdvanced Synthesis & Catalysis, 2004
- Lewis Acid Catalysis in Supercritical Carbon Dioxide. Use of Poly(ethylene glycol) Derivatives and Perfluoroalkylbenzenes as Surfactant Molecules Which Enable Efficient Catalysis in ScCO2The Journal of Organic Chemistry, 2004
- Catalytic Action of Azolium Salts. IX. Synthesis of 6-Aroyl-9H-purines and Their Analogues by Nucleophilic Aroylation Catalyzed by Imidazolium or Benzimidazolium Salt.CHEMICAL & PHARMACEUTICAL BULLETIN, 1998