Metabolic studies on retinoic acid in the rat
- 1 March 1971
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 122 (1), 1-4
- https://doi.org/10.1042/bj1220001
Abstract
The nature of metabolites in the urine arising from differentially labelled retinoic acid was investigated after injection of physiological doses into retinol-deficient rats. Distribution of radioactivity after partition of urine into ether-soluble, acidic and water-soluble fractions revealed that there were at least six metabolites in urine. Of these, the major metabolite(s) was one lacking both C-14 and C-15 of retinoic acid. Enzymic or alkaline hydrolysis of acidic and water-soluble fractions did not release any retinoic acid, thus indicating that retinoyl β-glucuronide was not present in urine in significant amounts.Keywords
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