Cyclic Adenosine Monophosphate and Hypertension in Rats
- 23 February 1973
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 179 (4075), 807-809
- https://doi.org/10.1126/science.179.4075.807
Abstract
Aortas from spontaneously hypertensive and stress hypertensive rats contained significantly lower intracellular concentrations of cyclic adenosine monophosphate than did their respective controls. Adenylate cyclase activity was normal but was less responsive to stimulation, while phosphodiesterase activity (especially the low Michaelis-Menten constant form) was significantly elevated. Human aortas contained two forms of phosphodiesterase that were similar to those in rat aortas.Keywords
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