The enkephalins and opiates: structure-activity relations
- 1 September 1977
- journal article
- review article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 29 (1), 257-265
- https://doi.org/10.1111/j.2042-7158.1977.tb11308.x
Abstract
The X-ray structures of 9 ‘opiate’ drugs which exhibit a range of pharmacological activity have been examined in detail leading to the theory that one of the reasons why the enkephalins and related peptides possess morphine-like activity is because they have a tyrosine, and hence a ‘tyramine’, residue at the amino terminal position. This residue or a conformationally similar moiety, can be shown to be present in many opiates and analogues.This publication has 68 references indexed in Scilit:
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