At how many histocompatibility loci do congenic mouse strains differ?
- 1 January 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Heredity
- Vol. 72 (1), 27-31
- https://doi.org/10.1093/oxfordjournals.jhered.a109420
Abstract
An expression is derived for the probability that a congenic strain and its inbred partner will differ by multiple linked histocompatibility genes when the number of incompatibilities between the original donor and background strains is known and the number of backcrosses to produce the strain is specified. This probability is shown to be rather large for typical values of the pertinent variables. Potential complications in data interpretation arising from unsuspected multiple incompatibilities between a congenic pair are discussed in relation to antigenic strength, H-locus polymorphism, tissue distribution of H antigens, and certain types of experiments in which the cell-mediated lympholysis assay is used.This publication has 2 references indexed in Scilit:
- H-2 effects on cell-cell interactions in the response to single non-H-2 alloantigens. I. Donor H-2D region control of H-7.1-immunogenicity and lack of restriction in vivo.The Journal of Experimental Medicine, 1977
- A New Histogenetic Method for Minor Histocompatibility Antigen TypingThe Journal of Immunology, 1977