Localization of autosomal recessive early‐onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset
- 31 January 2002
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 51 (2), 253-256
- https://doi.org/10.1002/ana.10106
Abstract
Two new loci, PARK6 and PARK7, for autosomal recessive early‐onset parkinsonism have recently been identified on chromosome 1p, in single large pedigrees. Among 4 autosomal recessive early‐onset families analyzed here, 2 supported linkage to PARK7, 1 with conclusive evidence. These data confirm localization of autosomal recessive early‐onset parkinsonism to PARK7, suggesting it to be a frequent locus. Assignment of families to either PARK6 or PARK7 might be difficult because of the proximity of the two loci on chromosome 1p.Keywords
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