Inhibition by 5‐(tetradecyloxy)‐2‐furoic acid of fatty acid and cholesterol synthesis in isolated rat hepatocytes
- 1 October 1977
- Vol. 12 (10), 814-818
- https://doi.org/10.1007/bf02533270
Abstract
Fatty acid and cholesterol synthesis in isolated rat hepatocytes were strongly inhibited by 5-(tetradecyloxy)-2-furoic acid. With either3H2O or [2-14C]acetate as the labeled precursor, the concentrations of inhibitor causing 50% decrease in fatty acid and cholesterol synthesis were, respectively, +]/[NADH] was decreased. Other parameters were unaffected. Both its potency and its specificity indicate that 5-(tetradecyloxy)-2-furoic acid will be useful in studies on the regulation of lipid biosynthesis.Keywords
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