Complement-fixing Antibody Responses to ECHO Virus Types 12 and 19 of Patients with Enterovirus Infections.

Abstract

Sera from 167 patients with various enterovirus infections were tested against uninactivated CF antigens to ECHO virus types 12 and 19. Four-fold or greater rises in CF antibody titer, unassociated with the presence of neutralizing antibody to these 2 ECHO virus types, were seen in an appreciable proportion of patients infected with ECHO 4, 6, 9 and 11 viruses, possibly indicating antigenic relationships of the viral moieties responsible for production of CF antibodies in man. No evidence was seen of a relationship between ECHO types 12 and 19 and ECHO 5, ECHO 10 (reoviruses) or ECHO 14, nor was there any good evidence of a relationship between these 2 ECHO virus types and the Coxsackie group A, Coxsackie group B or polio-virus types studied.