The Excretion of DDT (2,2-Bis-(P-Chlorophenyl)-1,1,1-Trichloroethane) in Man, Together with Clinical Observations

Abstract

The excretion of DDT was studied in one human subject, with a clinical study to detect any possible toxic symptoms. The ingestion of 11 mg./kg. body wt. dissolved in olive oil, corresponding to a total dose of 770 mg., caused no detectable toxic effects; part of the DDT was metabolized to di-(p-chlorophenyl)-acetic acid and excreted in the urine, maximally on the 2d day, decreasing rapidly on the 3d and 4th days, and diminishing gradually during the subsequent 10 days.