A new preparation of the isolated intact trachea of the guinea-pig
- 1 January 1970
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 22 (1), 46-50
- https://doi.org/10.1111/j.2042-7158.1970.tb08383.x
Abstract
A preparation is described in which the guinea-pig isolated intact trachea is subjected to repeated transmural electrical stimulation with alternating square wave pulses. The intraluminal pressure is continuously sensed by a pressure transducer. An increase in the intraluminal pressure is the predominant response to electrical stimulation. This response is prevented by low concentrations of atropine. After the initial rise a small fall in intraluminal pressure occurs; this is prevented by low concentrations of propranolol. The sensitivity of the preparation to various drugs is described.Keywords
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