Electrophoretic studies of ox serum. 2. The sera of cattle infected with the virus of foot-and-mouth disease

Abstract

Sera of 21 cattle were analyzed electrophoretically during the course of infection with the virus of foot-and-mouth disease. Six strains of virus were employed and a regular development of the electrophoretic distr. was observed in all but one of the 21 series of sera. In the serum of the "average typical animal" the beta-globulin rose from the normal level of 10 to about 14% on the 7th day following inoculation. The normal level of beta-globulin was regained during the following week. The gamma-globulin component increased from the normal level of 30 to about 40% during the 3rd or 4th wk. and maintained this value with little change for several wks. The gamma-globulin component in ox serum comprises at least 3 minor components which have been characterized by their mobility ranges. The observed increment in gamma-globulin arose in the components of lowest mobility.