The different stages in the medical use of Teflon are recalled. After animal experimentation which started in 1949, Teflon has been used in humans since 1962 in otorhinolaryngology, since 1973 in urology and, more recently, since 1984 in the treatment of vesicorenal reflux. The long-term future is still uncertain, especially with regard to children, for whom life expectancy is long.