Thrombin-stimulated cell division involves proteolysis of its cell surface receptor
- 1 April 1979
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 278 (5706), 711-714
- https://doi.org/10.1038/278711a0
Abstract
A cell-surface component of MW 43,000 was cleaved by thrombin on [chick-embryo] cells that divide after thrombin treatment, but was not cleaved on cells that are unresponsive to its mitogenic action. Studies with a photoreactive derivative of thrombin showed that its cell surface receptor has a MW of 43,000 and indicated that thrombin must cleave its receptor to stimulate cell division.This publication has 19 references indexed in Scilit:
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