Total and regional coronary blood flow during acute coronary occlusion in anaesthetized and conscious dogs

Abstract

Total and regional coronary blood flow was measured with radioactive microspheres before and early after the occlusion of the anterior descending coronary artery. A radial gradient of flow was found in the ' infarcted' area, the outer zone having a larger flow per gram of tissue than the inner one. The results suggest that this gradient is influenced by the aortic pressure. In the non-infarcted regions, a decrease in the coronary resistance was found in the left and right ventricular walls and in the atrial walls.