A SYNDROME CHARACTERIZED BY PREMENSTRUAL DERMATOSIS, POLYHYPERMENORRHEA, DYSMENORRHEA, MENSTRUAL HEADACHE AND AN INCREASED URINARY EXCRETION OF SODIUM PREGNANEDIOL GLUCURONIDE

Abstract

A patient is described whose symptoms included cyclic ecchymotic lesions during the latter part of the progestational phase of the cycle, polyhypermenorrhea, dysmenorrhea and menstrual headache. She was found to excrete an abnormally large amt. of sodium pregnandiol glucuronide in the urine. Intensive estrogenic therapy reduced these abnormal urinary titers and resulted in the disappearance of all the symptoms. An increased formation and metabolism of progesterone was thought to be related to the symptomatology of the patient.