Molecular insights into the physiology of the ‘thin film’ of airway surface liquid
- 1 May 1999
- journal article
- review article
- Published by Wiley in The Journal of Physiology
- Vol. 516 (3), 631-638
- https://doi.org/10.1111/j.1469-7793.1999.0631u.x
Abstract
The epithelia that line the airways of the lung exhibit two general functions: (1) airway epithelia in all regions 'defend' the lung against infectious and noxious agents; and (2) airway epithelia in the proximal regions replenish water lost from airway surfaces, i.e. the 'insensible water loss', consequent to conditioning inspired air. How airway epithelia perform both functions, and co-ordinate them in health and disease, is the subject of this review.Keywords
This publication has 30 references indexed in Scilit:
- Osmotic water permeabilities of cultured, well-differentiated normal and cystic fibrosis airway epitheliaJournal of Clinical Investigation, 2000
- Coordinated clearance of periciliary liquid and mucus from airway surfaces.Journal of Clinical Investigation, 1998
- Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4.Journal of Clinical Investigation, 1997
- The Aquaporin Family of Water Channel Proteins in Clinical MedicineMedicine, 1997
- Na+/K+ATPase in Lower Airway Epithelium from Cystic Fibrosis and Non-Cystic-Fibrosis LungBiochemical and Biophysical Research Communications, 1997
- Selective response of human airway epithelia to luminal but not serosal solution hypertonicity. Possible role for proximal airway epithelia as an osmolality transducer.Journal of Clinical Investigation, 1994
- Altered Fluid Transport Across Airway Epithelium in Cystic FibrosisScience, 1993
- Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)Cell, 1992
- Demonstration That CFTR Is a Chloride Channel by Alteration of Its Anion SelectivityScience, 1991
- Composition and control of secretions from tracheal bronchial submucosal glandsNature, 1979