THE EFFECTS OF INTRACISTERNAL SARIN AND PYRIDINE‐2‐ALDOXIME METHYL METHANESULPHONATE IN ANAESTHETIZED DOGS
Open Access
- 1 March 1960
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 15 (1), 170-174
- https://doi.org/10.1111/j.1476-5381.1960.tb01227.x
Abstract
Dogs poisoned by the anticholinesterase sarin could be saved by intravenous administration of atropine sulphate together with a suitable oxime. The central effects of intracisternal sarin were respiratory paralysis and vasomotor stimulation. The problem arose as to whether the oxime, being a quaternary nitrogen compound, could enter the brain from the blood, and could have a central action on the paralysed respiration. The methyl methanesulphonate of pyridine-2-aldoxime administered intracisternally, after sarin poisoning by the same route, was ineffective; atropine, given intravenously, was effective. The central and peripheral effects of sarin were thus reversed by the atropine-oxime therapy, the central effects by atropine, the peripheral by the oxime.Keywords
This publication has 18 references indexed in Scilit:
- THE EFFECT OF SOME OXIMES IN SARIN POISONINGBritish Journal of Pharmacology and Chemotherapy, 1958
- THE TOXICITY OF 2‐HYDROXYIMINOMETHYL‐NMETHYLPYRIDINIUM METHANESULPHONATE (P2S)British Journal of Pharmacology and Chemotherapy, 1958
- Experiments on the fate of histamine and acetylcholine after their injection into the cerebral ventriclesThe Journal of Physiology, 1958
- PROTECTION AGAINST THE LETHAL EFFECTS OF ORGANO‐PHOSPHATES BY PYRIDINE‐2‐ALDOXIME METHIODIDEBritish Journal of Pharmacology and Chemotherapy, 1957
- Histochemical Demonstration of Reactivation of Acetylcholinesterase in vivoScience, 1957
- Pyridine-2-Aldoxime Methiodide and Poisoning by AnticholinesterasesScience, 1957
- THE NATURE OF THE TOXICITY OF 2‐OXO‐OXIMESBritish Journal of Pharmacology and Chemotherapy, 1956
- THE CEREBRAL DISTRIBUTIONS OF A TERTIARY AND A QUATERNARY ANTICHOLINESTERASE AGENT FOLLOWING INTRAVENOUS AND INTRAVENTRICULAR INJECTION1956
- THE EFFECT OF ANTI‐CHOLINESTERASE AGENTS ON THE RAT'S BLOOD PRESSUREBritish Journal of Pharmacology and Chemotherapy, 1955
- THE FAILURE OF RESPIRATION IN DEATH BY ANTICHOLINESTERASE POISONINGBritish Journal of Pharmacology and Chemotherapy, 1953