Diazepam inhibits cell respiration and induces fragmentation of mitochondrial reticulum
- 14 November 1983
- journal article
- Published by Wiley in FEBS Letters
- Vol. 163 (2), 311-314
- https://doi.org/10.1016/0014-5793(83)80842-4
Abstract
Diazepam (70–150 μg/ml) significantly inhibits oxygen consumption by pig kidney embryo cells and causes the cellular ATP level to fall. The maximum inhibitory effect develops after 1.5–2.5 h of diazepam treatment. In isolated mitochondria diazepam inhibits respiration in state 2 and 3u with glutamate and in state 3u with succinate. Ethylrhodamine staining and electron microscopic study reveal fragmentation of mitochondria in living cells.Keywords
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