DNA topoisomerase dysfunction: A new goal for antitumor chemotherapy
- 1 April 1990
- Vol. 12 (4), 167-172
- https://doi.org/10.1002/bies.950120405
Abstract
Topoisomerase enzymes – found in prokaryotes to human cells – control conformational changes in DNA and aid the orderly progression of DNA replication, gene transcription and the separation of daughter chromosomes at cell division. Several classes of anti‐cancer drugs are now recognised as topoisomerase poisons because of their ability to trap topoisomerase molecules on DNA as ‘cleavable complexes’. Understanding how drugs generate such complexes and why they are toxic to actively growing cancer cells is a major challenge for the development of modern approaches to chemotherapy.Keywords
This publication has 36 references indexed in Scilit:
- Mitogen-induced topoisomerase II synthesis precedes DNA synthesis in human breast cancer cellsBiochemical and Biophysical Research Communications, 1989
- ADP-ribosylation of ADPR-transferase and topoisomerase I in intact mouse epidermal cells JB6Biochemistry, 1989
- A role of DNA topoisomerases in the active dissociation of DNA minor groove-ligand complexesMutation Research/DNA Repair, 1989
- The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding ProteinsScience, 1988
- DNA topoisomerases and DNA repairBioEssays, 1988
- Hotspot sites for acridine-induced frameshift mutations in bacteriophage T4 correspond to sites of action of the T4 type II topoisomeraseJournal of Molecular Biology, 1988
- Increment of DNA topoisomerases in chemically and virally transformed cellsExperimental Cell Research, 1988
- A mammalian cell mutant with enhanced capacity to dissociate a bis-benzimidazole dye-DNA complexCarcinogenesis: Integrative Cancer Research, 1988
- Isolation of intercalator-dependent protein-linked DNA strand cleavage activity from cell nuclei and identification as topoisomerase IIBiochemistry, 1986
- Relationship between a chromatin anomaly in ataxia-telangiectasia cells and enhanced sensitivity to DNA damageCarcinogenesis: Integrative Cancer Research, 1984