Requirements for effective IgE cross‐linking on mast cells and basophils
- 30 June 2006
- journal article
- review article
- Published by Wiley in Molecular Nutrition & Food Research
- Vol. 50 (7), 620-624
- https://doi.org/10.1002/mnfr.200500272
Abstract
This article reviews the characteristics of high affinity IgE receptors (FcεRI) and their role in the response to allergenic proteins. The requirements for successful cross‐linking of FcεRI on basophils and mast cells and subsequent degranulation by allergenic proteins will be explained in detail. Methods for in vitro analysis of allergen‐induced mast cell and basophil degranulation will be described and issues/problems in applying these methods will be discussed. Finally, implications for manipulation of protein allergens will be discussed.Keywords
This publication has 44 references indexed in Scilit:
- A Lipid Raft Environment Enhances Lyn Kinase Activity by Protecting the Active Site Tyrosine from DephosphorylationJournal of Biological Chemistry, 2003
- Allergen immunotherapy: does it work and, if so, how and for how long?Thorax, 2000
- Impaired IgG-Dependent Anaphylaxis and Arthus Reaction in FcγRIII (CD16) Deficient MiceImmunity, 1996
- Rat basophil leukaemia (RBL) cells sensitized with low affinity IgE respond to high valency antigenClinical and Experimental Allergy, 1996
- FcϵRI on human Langerhans cells: a receptor in search of new functionsImmunology Today, 1994
- Fc ReceptorsAnnual Review of Immunology, 1991
- Differential activation of human basophils by anti‐IgE and formyl‐methionyl‐leucylphenylalanine. Indications for protein kinase C‐dependent and ‐independent activation pathwaysEuropean Journal of Immunology, 1991
- Cross-Linking of IgE-receptor complexes at the cell surface: Synthesis and characterization of a long bivalent hapten that is capable of triggering mast cells and rat basophilic leukemia cellsMolecular Immunology, 1986
- Studies on Human Basophil ReleasabilityInternational Archives of Allergy and Immunology, 1985