Prospective evaluation of changes in computed cranial tomography in patients with small cell lung carcinoma treated with chemotherapy and prophylactic cranial irradiation.
- 1 October 1984
- journal article
- research article
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 2 (10), 1151-1156
- https://doi.org/10.1200/jco.1984.2.10.1151
Abstract
Computed cranial tomographic scans were performed as part of the pretreatment evaluation and at six- to nine-month intervals posttreatment in 13 patients with small cell lung carcinoma. All patients received 3,000 rad of prophylactic cranial irradiation delivered over two weeks in ten treatment fractions in conjunction with multiagent chemotherapy. Posttreatment scans documented an extraordinarily high frequency of abnormalities including cerebral atrophy (100%), ventricular dilatation (70%), and decreased coefficient of absorption in the white matter (15%). Unexplained neurologic abnormalities developed in four of six patients living at least 15 months after institution of therapy. As the number of long-term survivors of this type of lung cancer increases, the need for prospective comprehensive neuropsychologic assessment to determine the clinical significance of these changes is needed.This publication has 13 references indexed in Scilit:
- Cerebellar Atrophy Developing After Cranial IrradiationJournal of Computer Assisted Tomography, 1982
- The effects of prophylactic treatment of the central nervous system on the intellectual functioning of children with acute lymphocytic leukemiaAmerican Journal Of Medicine, 1981
- Computed tomography brain scans in long term survivors of childhood acute lymphoblastic leukemiaMedical and Pediatric Oncology, 1981
- Computed tomography brain scans in children with acute lymphocytic leukemia receiving methotrexate alone as central nervous system prophylaxisCancer, 1980
- Reversible Cerebral Atrophy in Recently Abstinent Chronic Alcoholics Measured by Computed Tomography ScansScience, 1978
- Abnormal CT Scans of the Brain in Asymptomatic Children with Acute Lymphocytic Leukemia after Prophylactic Treatment of the Central Nervous System with Radiation and Intrathecal ChemotherapyNew England Journal of Medicine, 1978
- Steroids and Apparent Cerebral Atrophy on Computed Tomography ScansJournal of Computer Assisted Tomography, 1978
- Retrospective study of intellectual development in children treated for acute lymphoblastic leukaemia.Archives of Disease in Childhood, 1977
- Prophylactic cranial irradiation in small cell carcinoma of the lung. A randomized studyJAMA, 1977
- Five years after central nervous system irradiation of children with leukemiaInternational Journal of Radiation Oncology*Biology*Physics, 1976