Histamine Shock and Vitamins

Abstract

Vits. B1; B12, C, K, and B complex, given subcut. (up to 10 mg., 30 [mu]g., 100 mg., 10 mg. and 1 cc./kg., resp.) to guinea pigs 20 min. before exposure to histamine aerosol, did not prevent histamine shock. Vit. B12, up to 15 [mu]g./kg. intraven. in cats and up to 20 [mu]g./kg. in guinea pigs did not change the vasodepressor effect of intraven. 0.25 [mu]g./kg. histamine, nor did vit. B12 in concns. up to 0.6 ug./ml. or vit. C up to 100 mg./ml. alter the response of excised guinea pig ileum to 0.02 [mu]g/ml. histamine.