THE COMPARATIVE ACTIVITY OF DESOXYCORTICO-STERONE ACETATE AND PROGESTERONE IN ADRENAL-ECTOMIZED RATS

Abstract

[female] albino rats were adrenalectomized in 2 stages at 25 and 30 days of age. One mg. of desoxycorticosterone acetate daily, intramusc, was beneficial in prolonging life and maintaining considerable growth. Smaller amts., 1/4-1/2 mg. daily, also had a noticeable effect. Adrenalectomized rats injected daily with 1 mg. of progesterone gave a growth curve similar to the growth curve obtained under the same conditions with desoxycorticosterone acetate. The similarity between desoxycorticosterone acetate and progesterone is described.