Development of autoimmune insulitis is prevented in Eαd but not in Aβk NOD transgenic mice

Abstract

Two lines of Eα^d-expressing NOD mice were established by continuously backcrosslng [Eα^d B6 transgenic mice × NOD] F1 to parental NOD or directly microinjecting the Eα^d gene into fertilized NOD eggs. Similarly, Aβ^k-expressing transgenic NOD mice were produced. Subsequent histological examination of pancreatic tissues revealed that autoimmune insulitls was prevented in Eα^d backcross and transgenic mice but not in Aβ^k transgenic mice.