ON THE ROLE OF SOLUBLE RIBONUCLEIC ACID IN CODING FOR AMINO ACIDS
- 1 June 1962
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 48 (6), 1086-1092
- https://doi.org/10.1073/pnas.48.6.1086
Abstract
A direct test is made of the hypothesis that sRNA functions as an adaptor in specifying the fit of amino acids on a template. Cystein, attached to its normal acceptor sRNA is converted, while still attached to alanine, by reduction with Raney Nickel. The coding properties of the resultant hybrid are examined by the use of poly UG which stimulates incorporation into peptide of cysteine but not alanine. Alanine, attached to the cystein acceptor is incorporated, indicating that the adaptor hypothesis is correct.Keywords
This publication has 13 references indexed in Scilit:
- Ribonucleotide composition of the genetic codeBiochemical and Biophysical Research Communications, 1962
- SYNTHETIC POLYNUCLEOTIDES AND THE AMINO ACID CODE, IVProceedings of the National Academy of Sciences, 1962
- The Dependence of Reactions Catalyzed by Polynucleotide Phosphorylase on OligonucleotidesJournal of Biological Chemistry, 1962
- AN INTERMEDIATE IN THE BIOSYNTHESIS OF POLYPHENYLALANINE DIRECTED BY SYNTHETIC TEMPLATE RNAProceedings of the National Academy of Sciences, 1962
- SYNTHETIC POLYNUCLEOTIDES AND THE AMINO ACID CODEProceedings of the National Academy of Sciences, 1961
- EXPERIMENTS ON HEMOGLOBIN BIOSYNTHESISProceedings of the National Academy of Sciences, 1961
- AMINO ACID TRANSFER FROM AMINOACYL-RIBONUCLEIC ACIDS TO PROTEIN ON RIBOSOMES OF ESCHERICHIA COLIProceedings of the National Academy of Sciences, 1961
- A SOLUBLE RIBONUCLEIC ACID INTERMEDIATE IN PROTEIN SYNTHESISJournal of Biological Chemistry, 1958
- On protein synthesis.1958
- BIOSYNTHESE DES CYSTEINS AUS SERIN UND SCHWEFELWASSERSTOFF1957