Ultrastructural changes in skeletal muscles in dengue virus‐infected mice

Abstract
Dengue type 2 virus was inoculated intracerebrally in 20 adult swiss albino mice. Thigh muscles were removed after 24 h 3, 5 and 7 days after virus inoculation. Electron microscopic studies of the striated muscles show destruction of myofibrils, rarification of the sarcoplasmic reticulum network and changes in the mitochondria. Aggregates of electron‐dense material as well as glycogen particles were also seen in the cytoplasm.