Incomplete Restoration of the Bursa-Dependent Immune System After Transplantation of Allogeneic Stem Cells into Immunodeficient Chicks
- 1 March 1974
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 71 (3), 957-961
- https://doi.org/10.1073/pnas.71.3.957
Abstract
Transplantation of allogeneic cells from bursa of Fabricius into cyclophosphamide-treated, immunodeficient chicks resulted in immunological tolerance to donor line skin grafts; graft-versus-host disease did not occur. Allogeneic bursal stem cells taken from 3-day-old donors induced restoration of bursal morphology, of antibody formation to Brucella abortus and of occurrence of pyroninophilic cells and immunoglobulin-bearing cells in the peripheral lymphoid tissues. Secondary response to sheep red blood cells and production of germinal centers were not restored. Transplantation of histocompatible bursal stem cells resulted in a complete reconstitution of the bursa-dependent lymphoid system, both in function and in morphology. Allogeneic postbursal stem cells taken from the bursa of 10-week-old donors had a reconstitutive effect only on the production of antibodies to Brucella. Transplanted stem cells maintained their functional potential in the allogeneic environment, since, when transferred back to histocompatible hosts, they displayed normal function. These findings indicate that a complete functional and morphological restoration of the bursa-dependent immune system cannot be achieved without identity of the donor and recipient at loci near to or identical with those determining the major histocompatibility antigens, even though graft-versus-host disease is avoided. This identity permits a full cooperation of the donor and host cells.Keywords
This publication has 14 references indexed in Scilit:
- Bursal and postbursal stem cells in chicken. functional characteristicsEuropean Journal of Immunology, 1973
- CELL INTERACTIONS BETWEEN HISTOINCOMPATIBLE T AND B LYMPHOCYTESThe Journal of Experimental Medicine, 1973
- Immunocompetent cells in the chicken: II. Synergism between thymus cells and either bursa or bone marrow cells in the humoral immune response to sheep erythrocytesCellular Immunology, 1973
- Thymus TransplantationNew England Journal of Medicine, 1973
- CELL INTERACTIONS BETWEEN HISTOINCOMPATIBLE T AND B LYMPHOCYTESThe Journal of Experimental Medicine, 1973
- Recent advances in transplantation of incompatible marrow in infants with combined immunodeficiency disease.1973
- GENETIC CONTROL OF GRAFT-VERSUS-HOST COMPETENCETransplantation, 1972
- Commercial Glycol-Base Antifreeze with Added Detergent as a frozen Section Clarifier and Adherence AidStain Technology, 1972
- Treatment of Lymphopenic Hypogammaglobulinemia and Bone-Marrow Aplasia by Transplantation of Allogeneic MarrowNew England Journal of Medicine, 1969