Neoantigenic Expressions Engendered by Plasmin Cleavage of Fibrinogen

Abstract

Cleavage of fibrinogen to its pathophysiologic fragments by plasmin is associated with the appearance of unique neoantigens recognizable by Ouchterlony and radioimmunochemical techniques. Recognition of these cleavage-specific neoantigens by antisera to fibrinogen D-fragment introduces additional molecular markers for the study of fibrinogen conformation and also may permit direct assay of plasma for fibrinogen cleavage.