Significant linkage to chromosome 22q for exploratory eye movement dysfunction in schizophrenia
- 28 July 2003
- journal article
- research article
- Published by Wiley in American Journal Of Medical Genetics Part B-Neuropsychiatric Genetics
- Vol. 123B (1), 27-32
- https://doi.org/10.1002/ajmg.b.10046
Abstract
A genome‐wide scan for a locus responsible for exploratory eye movement (EEM), which is quantitative and can be disturbed in association with schizophrenia, was performed. A 10‐cM resolution genome‐wide linkage analysis of the EEM disturbance with 358 highly polymorphic microsatellite markers in 38 nuclear families with 122 members (38 probands, 47 sibs, and 37 parents) including 58 sib‐pairs yielded the suggestive linkage to the GCT10C10 marker on chromosome 22q11.2 (LOD = 2.48). Dense mapping with additional markers around the GCT10C10 marker yielded evidence for significant linkage between EEM disturbance and markers D22S429 and D22S310 on chromosome 22q12.1 (LOD score of 4.63) with suggestive evidence for the chromosome region 22q11.2–q12.1. Our findings suggest that a relatively small number of loci may control the schizophrenia‐related quantitative EEM trait. We believe that identifying gene(s) on chromosome 22q associated with the EEM phenotype may forward our understanding of the etiology of schizophrenia.Keywords
This publication has 35 references indexed in Scilit:
- Eye movement dysfunction in schizophrenia: A heritable characteristic for enhancing phenotype definitionAmerican Journal of Medical Genetics, 2000
- Testing for linkage of eye tracking dysfunction and schizophrenia to markers on chromosomes 6, 8, 9, 20, and 22 in families multiply affected with schizophreniaAmerican Journal of Medical Genetics, 1999
- Alternative phenotypes for the complex genetics of schizophreniaBiological Psychiatry, 1999
- Psychophysiological measures of (dis)inhibition as liability indicators for schizophreniaPsychophysiology, 1998
- Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21Nature Genetics, 1998
- Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locusProceedings of the National Academy of Sciences, 1997
- Eye tracking dysfunction is a putative phenotypic susceptibility marker of schizophrenia and maps to a locus on chromosome 6p in families with multiple occurrence of the diseaseAmerican Journal of Medical Genetics, 1996
- A combined analysis of D22S278 marker alleles in affected sib-pairs: Support for a susceptibility locus for schizophrenia at chromosome 22q12American Journal of Medical Genetics, 1996
- Analysis of chromosome 22 markers in nine schizophrenia pedigreesAmerican Journal of Medical Genetics, 1994
- Confirming Unexpressed Genotypes for SchizophreniaArchives of General Psychiatry, 1989