The reactivity of murine lymphocytes to epidermal cells.

Abstract

Epithelial cells are effective targets for lymphocyte stimulation in vitro. The magnitude of response to incompatible epithelial cells was equal to or slightly greater than that following incubation with lymphoid cells. Lymph node lymphocytes appear slightly more reactive to epithelia than comparable preparations of spleen cells. This model was used to study whether differentiation antigens of skin (Sk) which are not expressed on lymphoid cells can provoke an in vitro allograft reaction.