Evaluation of Elastomers for Biomedical Applications Utilizingin vivoandin vitroModel Systems—State of the Art and Future Trends

Abstract

The increased use of natural and synthetic materials for biomedical applications has given emphasis to the need for determining the biocompatibility of materials in a rapid and reproducible manner. This report summarizes classical in vivo techniques and describes the evaluation for biocompatibility of a series of thermoplastic and crosslinked elastomers as well as a series of phthalic acid esters utilizing three recently developed in vitro methods of tissue culture.