When rabbits are exposed to x-radiation as described, there results a definite change in the See PDF for Equation ratio of their plasma. This change is evidently one which defines a state of uncompensated alkali excess. The time required for a maximum change in the chemical reaction is the same as that required for a maximum change in the decrease of leucocytes. Sodium bicarbonate injected into the peritoneal cavity is followed by results identical with those observed following exposure to x-rays. The maximum changes occur in a shorter time following bicarbonate injection, but the relation between chemical and morphological changes are the same. We consider this analogy to be an important one in that it is suggestive of a relationship between the effect of salt and the effect of x-rays.