Christmas Factor: Dosage Compensation and the Production of Blood Coagulation Factor IX
- 25 January 1963
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 139 (3552), 348-349
- https://doi.org/10.1126/science.139.3552.348
Abstract
The amount of factor IX (Christmas factor) for different genotypic classes was determined by means of a variant of the thromboplastin generation test. The mean value for females heterozygous for the Christmas gene was about half the mean values for normal males and for normal homozygous females; means for the latter two groups were about equal. This dosage compensation is interpreted as evidence in support of Lyon's hypothesis, according to which one X chromosome is inactive in mammalian females.Keywords
This publication has 3 references indexed in Scilit:
- THE NORMAL HUMAN FEMALE AS A MOSAIC OF X-CHROMOSOME ACTIVITY: STUDIES USING THE GENE FOR G-6-PD-DEFICIENCY AS A MARKERProceedings of the National Academy of Sciences, 1962
- Gene Action in the X-chromosome of the Mouse (Mus musculus L.)Nature, 1961
- The Thromboplastin Generation TestJournal of Clinical Pathology, 1953