Blood Levels and Urinary Excretion in Peanut Oil, Beeswax and Penicillin Mixture

Abstract

Penicillin in a conc, of 100,000 units/ml, in a mixt. of peanut oil and 4% white beeswax was detectable in significant amts. in the blood for over 5 hrs., as compared with a 3-4 hr. level for water or saline penicillin solns. following its intramusc. injn. into human patients in a single dose of 200,000 units. The urine and blood were assayed by the serial dilution "turbidimetric" method of Dawson and Hobby. Penicillin was present in the urine in greater cone, and for much longer intervals than in the blood, the conc, being 100-600 times.