2,2,2-Trichloroethylsulphonyl, 2,2,2-trichloroethoxysulphonyl, and trifluoroacetyl isocyanates in β-lactam synthesis

Abstract

Condensation of the title isocyanates with olefins and subsequent dissolving-metal reduction (sulphonyl derivatives) or chromatography on Florisil (trifluoroacetyl derivatives) gave several N-unsubstituted β-lactams including two 8-aza-2-oxabicyclo[4.2.0]octan-7-one derivatives.