The Intravenous, Intraperitoneal, and Subcutaneous Routes of Insulin Delivery in Diabetic Man
- 1 December 1979
- journal article
- research article
- Published by American Diabetes Association in Diabetes
- Vol. 28 (12), 1069-1072
- https://doi.org/10.2337/diab.28.12.1069
Abstract
Successful implantation of an artificial pancreas requires the infusion of insulin into an appropriate anatomic site. Three sites being actively investigated include (1) intravenous (i.V.), (2) intraperitoneal (i.p.), and (3) subcutaneous (s.c). This study compared the rate, magnitude, and duration of insulin absorption from these three absorption sites as assessed by the appearance of “free” insulin into the plasma of 10 insulin-dependent diabetic subjects. The biologic effectiveness of insulin was assessed by the suppression of plasma glucose concentration following a 750-calorie meal. Our results suggest that i.v. delivered insulin provides the most rapid increase in plasma free insulin concentration, followed by the i.p. and s.c. routes, respectively. In contrast, the elevation of plasma free insulin concentration was most prolonged with the s.c. route, followed by i.p. and i.v. routes, respectively. Compared with the i.v. and s.c. routes of insulin delivery, only 50% of the i.p. delivered insulin appeared in the plasma. The onset of the biologic activity of the insulin delivered by the three different routes during the 4½-h observation period was most rapid for the i.v. and least rapid for the s.c. route. These results suggest that all three routes may be appropriate sites for delivery of insulin from an artificial pancreas. However, because of the difference in absorption kinetics and the onset of biologic effectiveness of the delivered insulin, different quantities and timing of insulin delivery may be needed.This publication has 4 references indexed in Scilit:
- Reduction to Normal of Plasma Glucose in Juvenile Diabetes by Subcutaneous Administration of Insulin with a Portable Infusion PumpNew England Journal of Medicine, 1979
- The peritoneal absorption of insulin in diabetic man: A potential site for a mechanical insulin delivery systemMetabolism, 1979
- Long-term continuous intravenous insulin therapy with a portable insulin dosage-regulating apparatusDiabetes, 1979
- Blood glucose regulation using an open-loop insulin delivery system in pancreatectomized dogs given glucose infusionsDiabetologia, 1979