Effects of thyrotrophic-releasing hormone (TRH) on thermoregulation in the rat

Abstract
At ambient temperatures (Ta) of both 8 and 22°C, intraventricular administration of TRH (10–80 μg) produced a dose-dependent hypothermia in rats. The hypothermia was due to both decreased metabolic heat production and cutaneous vasodilatation. In contrast, at 30°C Ta, TRH increased metabolic heat production (due to behavioral excitation) and led to hyperthermia.