Many cells in rat bone marrow have cell‐surface Thy‐1 antigen
- 1 July 1976
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 6 (7), 526-528
- https://doi.org/10.1002/eji.1830060716
Abstract
Thy-1.1 and Thy-1 xenoantigenic determinants were detected at the cell surface of many rat bone marrow cells. The absorptive capacity of bone marrow cells was 6–10 % of that of thymocytes for Thy-1 antigenic determinants, and 30–45 % of rat bone marrow cells were specifically labeled with anti-Thy-1 antibody as detected by autoradiography. Thus, while mice and rats are similar in having large amounts of Thy-1 in brain and thymocytes, they differ in that the rat lacks the antigen in most peripheral T cells and expresses it in a large number of bone marrow cells; the opposite is true in the mouse.This publication has 23 references indexed in Scilit:
- IgG2 and other immunoglobulin classes on the cell surface of rat lymphoid cellsEuropean Journal of Immunology, 1975
- Immunological restoration of both thymectomised and athymic nude mice by a thymus factorNature, 1975
- Antigens on mouse and rat lymphocytes recognized by rabbit antiserum against rat brain: The quantitative analysis of a xenogeneic antiserumEuropean Journal of Immunology, 1975
- Estimation of the amount and tissue distribution of rat Thy‐1.1 antigenEuropean Journal of Immunology, 1974
- High frequency of T lineage lymphocytes in nude mouse spleenNature, 1974
- The binding of anti‐immunoglobulin antibodies to rat thymocytes and thoracic duct lymphocytesEuropean Journal of Immunology, 1974
- DIFFERENTIATION OF T CELLS INDUCED BY PREPARATIONS FROM THYMUS AND BY NONTHYMIC AGENTSThe Journal of Experimental Medicine, 1973
- IN-VITRO DEMONSTRATION OF THYMIC HORMONE IN THE MOUSE BY CONVERSION OF PRECURSOR CELLS INTO LYMPHOCYTESThe Lancet, 1973
- OCCURRENCE OF A THETA-LIKE ANTIGEN IN RATSThe Journal of Experimental Medicine, 1972
- Thymus specific antigen on electrophoretically separated rat lymphocytes. Tracing of the differentiation pathway of bone marrow‐derived thymocytes by use of a surface markerEuropean Journal of Immunology, 1972