Inhibition of Tumor Promotion by a Biomimetic Superoxide Dismutase
- 1 July 1983
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 221 (4605), 75-77
- https://doi.org/10.1126/science.6857269
Abstract
A low molecular weight, lipophilic, copper coordination complex with superoxide dismutase-mimetic activity inhibited biochemical and biological actions of a tumor promoter in mouse epidermis. Such inhibitory effects implicate reactive oxygen species in the tumor promotion process.This publication has 21 references indexed in Scilit:
- Effects of Peroxides on Rodent Skin: Epidermal Hyperplasia and Tumor PromotionJournal of Investigative Dermatology, 1982
- Tumour promoter phorbol-12-myristate-13-acetate induces chromosomal damage via indirect actionNature, 1981
- Skin Tumor-Promoting Activity of Benzoyl Peroxide, a Widely Used Free Radical-Generating CompoundScience, 1981
- Cell division in normal and transformed cells: The possible role of superoxide and hydrogen peroxideMedical Hypotheses, 1981
- In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: Part 1CRC Critical Reviews in Toxicology, 1980
- Protease inhibitors antagonize the activation of polymorphonuclear leukocyte oxygen consumptionBiochemical and Biophysical Research Communications, 1979
- Copper chelates as possible active forms of the antiarthritic agentsJournal of Medicinal Chemistry, 1976
- Superoxide dismutase activity of low molecular weight Cu2+‐chelates studied by pulse radiolysisFEBS Letters, 1974
- Specific degranulation of human polymorphonuclear leukocytesNature, 1974
- Safety tests of orgotein, an antiinflammatory proteinToxicology and Applied Pharmacology, 1973