An excitatory nociceptive cardiac reflex elicited by bradykinin and potentiated by prostaglandins and myocardial ischaemia
- 1 May 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 10 (3), 314-327
- https://doi.org/10.1093/cvr/10.3.314
Abstract
Application of bradykinin to the exposed ventricular surface of the dog heart elicits a reflex cardiovascular response which includes a rise in blood pressure, tachycardia, renal vasoconstriction and muscular vasodilation. The reflex response depends on the dose of bradykinin and is increased by concomitant application of prostaglandin E1 or E2 and reduced by indomethacin. Temporary occlusion of the coronary artery supplying the area of the ventricle under study also sensitized the heart to topical application of bradykinin.This publication has 11 references indexed in Scilit:
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