FORMATION OF A DNA-SOLUBLE RNA HYBRID AND ITS RELATION TO THE ORIGIN, EVOLUTION, AND DEGENERACY OF SOLUBLE RNA
Open Access
- 1 December 1962
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 48 (12), 2101-2109
- https://doi.org/10.1073/pnas.48.12.2101
Abstract
It is possible to form ribonuclease-resistant hybrid complexes between sRNA and DNA. This suggests the existence of a sequence of nucleotides in the DNA complementary to the sRNA. When this complex is formed with an excess of sRNA, the DNA in one E. coli genome is saturated with approximately 40 sRNA molecules. If there is one site per sRNA molecule, this suggests that there is considerable degeneracy in the amino acid code. Hybrids have been formed between E. coli sRNA and DNA from a variety of bacterial species. Closer relatives form larger amounts of ribonuclease-resistant hybrid than distant relatives.Keywords
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