Carcinogenicity of benzo[a]pyrene 4,5-, 7,8-, and 9,10-oxides on mouse skin.
- 1 January 1976
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 73 (1), 243-247
- https://doi.org/10.1073/pnas.73.1.243
Abstract
Benzo[a]pyrene and three arene oxides of benzo[a]pyrene (benzo[a]pyrene 4,5-, 7,8-, and 9,10-oxides) have been tested for carcinogenicity in mice by topical application of each compound (0.1 or 0.4 mumol) once every 2 weeks for 60 weeks. At the high dose, benzo[a]pyrene and the 7,8-oxide were highly carcinogenic, whereas the 4,5-oxide (K-region oxide) was weakly active and the 9,10-oxide was inactive. At the low dose, only benzo[a]pyrene was highly carcinogenic. The carcinogenic activities of the three arene oxides of benzo[a]pyrene were not correlated with their stabilities or mutagenic activities.Keywords
This publication has 24 references indexed in Scilit:
- Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxideNature, 1974
- Arene Oxides: A New Aspect of Drug MetabolismScience, 1974
- Cell-mediated mutagenesis of mammalian cells with chemical carcinogensInternational Journal of Cancer, 1974
- Malignant transformation in vitro of mouse fibroblasts by 7, 12‐dimethylbenz(A)anthracene and 7‐hydroxymethylbenz(A)anthracene and by their K‐region derivativesInternational Journal of Cancer, 1974
- Facile synthesis of arene oxides at the K regions of polycyclic hydrocarbonsJournal of the American Chemical Society, 1974
- Metabolic conversion of benzo[a]pyrene by Syrian hamster liver microsomes and binding of metabolites to deoxyribonucleic acidJournal of Medicinal Chemistry, 1973
- Epoxides of Carcinogenic Polycyclic Hydrocarbons Are Frameshift MutagensScience, 1972
- The carcinogenic activities in mice of compounds related to benz[a]anthraceneInternational Journal of Cancer, 1967
- The carcinogenic activities in mice of compounds related to 3‐methylcholanthreneInternational Journal of Cancer, 1967
- Low Carcinogenicity of the K-Region Epoxides of 7-Methylbenz(a)-anthracene and Benz (a) anthracene in the Mouse and Rat.Experimental Biology and Medicine, 1967