Fluoride Levels in Human Parotid Saliva Following Ingestion of Fluoride Compounds of Varying Solubility

Abstract
Healthy dental students received oral doses of 10.0 mg F daily in the form of compounds of widely varying solubilities. Parotid saliva F concentration and urinary F excretion were highest with NaF, Na2 PO3 F, and SnF2 , lowest with CaF2 , and intermediate with AlF3 . Solubility of the ingested fluoride compound was a controlling factor in the amount of F excreted in the urine, the peak F concentration reached in parotid saliva, and the duration of a significant elevation in salivary F.