Virus isolation studies in Crohn's disease: a negative report.
Open Access
- 1 December 1979
- Vol. 20 (12), 1057-1062
- https://doi.org/10.1136/gut.20.12.1057
Abstract
Homogenates of gut and mesenteric lymph node tissue from patients with Crohn's disease, ulcerative colitis, and control patients were tested for cytopathic effect (CPE) production in a series of cell lines including rabbit ileal and W138 cells. A CPE was produced in W138 cells by tissue homogenates from patients with Crohn's disease, ulcerative colitis, and control patients. Evidence was obtained to suggest that this effect, although superficially similar to a viral CPE, was due to toxic protein constituents of inflamed tissue homogenate.Keywords
This publication has 11 references indexed in Scilit:
- Electron microscopy of viruses in inflammatory bowel diseaseGastroenterology, 1978
- ISOLATION OF REOVIRUS-LIKE AGENTS FROM PATIENTS WITH CROHN'S DISEASEThe Lancet, 1977
- FURTHER ELECTRON-MICROSCOPIC EVIDENCE OF VIRUS-LIKE PARTICLES IN CROHNS-DISEASE1977
- ELECTRON MICROSCOPIC STUDIES OF VIRAL AGENTS IN CROHN'S DISEASEThe Lancet, 1976
- CULTIVATION OF VIRAL AGENTS FROM CROHN'S DISEASEThe Lancet, 1976
- Isolation and characterization of a viral agent from intestinal tissue of patients with Crohn's disease and other intestinal disorders.1975
- Viral Investigations in Ulcerative Colitis and Regional EnteritisGastroenterology, 1973
- The gel-filtration behaviour of proteins related to their molecular weights over a wide rangeBiochemical Journal, 1965
- FACTORS IN THE AETIOLOGY OF REGIONAL ENTERITIS.1963
- Studies on the viral etiology of regional enteritis and ulcerative colitis: A negative reportDigestive Diseases and Sciences, 1962