Necrotizing Effects of Staphylococcus aureus Extract on Mouse Sarcoma 180.

Abstract

1) A trichloracetic acid extract of Staphylococcus aureus, strain D (5 to 40 μg/mouse), in 24 hours caused extensive hemorrhagic necrosis of Sarcoma 180 in HaICR Swiss mice when injected intraperi-toneally 7 days after tumor implantation. The extract was ineffective against tumors 1 to 4 days after implantation. 2) The effect was also produced in Sarcoma 180 grown in C57B1/6, C3H, AKR and DBA₂ mice. 3) Epinephrine, dibenzyline and the antihistaminic drug Benadryl, in the doses used, did not alter the necrotizing activity of the extract. Cortisone, however, reduced the incidence of the effect.