Cerebral MR and CT Imaging in Creutzfeldt-Jakob Disease

Abstract

Magnetic resonance (MR) imaging and CT [computed tomography] of 3 patients with Creutzfeldt-Jakob disease (CJD) showed bilateral cortical atrophy and no apparent white matter changes. Serial examinations revealed the progressive nature of the atrophy, findings compatible with the patients'' clinical deterioration. At autopsy some white matter abnormalities were detected in 1 patient 6 mo. after MR imaging. The white matter abnormalities, if present, apparently develop during the final stage of CJD.