Influence of Body Fat on Duration of Thiopental Anesthesia

Abstract

A 5 g.% decrease in body fat of the rat resulted In a 100% increase in length of thiopental anesthesia at a fixed thiopental dosage, or a 40% decrease in the amt. of thiopental required for a given duration of anesthesia. In contrast the duration of pentobarbital anesthesia was unaffected by the amt. of body fat.