This paper is an introduction to a multidisciplinary series of papers on the efficiency of human movement. The problem is posed by citing the example of the large variation in oxygen uptake (per kg body weight) within a typical group of subjects running at the same submaximal speed. An analog of the possible causes of this variation is presented where “set points” for biomechanical, physiological, psychological, biochemical, and other factors combine in series to influence the overall energy cost. The various definitions of “efficiency” and “economy” are considered at the whole body and the isolated muscle level, and a discussion of baseline subtraction is presented. The concept of “effectiveness” is reviewed to illustrate the interaction of skilled performance and energy cost. It is recommended that the terms “muscular efficiency ,” “muscle efficiency ,” “economy,” and “effectiveness” be used in their respective contexts to replace the current diversity of overlapping and, at times, confusing terminology.