Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium?
- 1 July 1994
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 36 (1), 97-100
- https://doi.org/10.1002/ana.410360118
Abstract
Allele frequencies for polymorphisms in the aplipoprotein E and the apolipoprotein CII genes were determined in subjects of Ashkenazi Jewish origin with lateonset Alzheimer's disease and in unaffected control subjects from the same ethnic group. A significant association was observed between late‐onset Alzheimer's disease and the ε4 (112Cys→Arg) allele of apolipoprotein E; however, no association was detected with apolipoprotein CII. These results suggest that the association with ε4 is probably not due to linkage disequilibrium.Keywords
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