Muscarinic cholinergic receptors in murine lymphocytes: demonstration by direct binding.
- 1 June 1978
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 75 (6), 2902-2904
- https://doi.org/10.1073/pnas.75.6.2902
Abstract
Using [3H]quinuclidinyl benzilate as a specific cholinergic muscarinic ligand, it was demonstrated that lymphocytes have muscarinic binding sites. There are approximately 200 sites/cell and the Kd for quinuclidinyl benzilate is approximately 1 .times. 10-9 M. Quinuclidinyl benzilate receptor binding is blocked by atropine and oxotremorine.This publication has 15 references indexed in Scilit:
- Occupancy of Muscarinic Acetylcholine Receptors Stimulates a Guanylate Cyclase in Neuroblastoma CellsBiochemical Society Transactions, 1977
- T-Lymphocyte precursors. I. Synergy between precursor and mature T lymphocytes in the response to concanavalin A.The Journal of Experimental Medicine, 1976
- Binding of agonists and antagonists to muscarinic receptorsJournal of Supramolecular Structure, 1976
- Emergence of Insulin Receptors on Human Lymphocytes During In Vitro TransformationProceedings of the National Academy of Sciences, 1972
- Acetylcholine Receptors: Number and Distribution at Neuromuscular Junctions in Rat DiaphragmScience, 1972
- Acetylcholine Receptors in Muscle FibresNature, 1971
- Use of a Snake Venom Toxin to Characterize the Cholinergic Receptor ProteinProceedings of the National Academy of Sciences, 1970
- AN EXTENSION OF THE51Cr-RELEASE ASSAY FOR THE ESTIMATION OF MOUSE CYTOTOXINSTransplantation, 1968
- The uptake of atropine and related drugs by intestinal smooth muscle of the guinea-pig in relation to acetylcholine receptorsProceedings of the Royal Society of London. B. Biological Sciences, 1965
- The release of acetylcholine from perfused sympathetic ganglia and skeletal musclesThe Journal of Physiology, 1956